Hypertrichosis a.k.a. "Wolf Man Disease"Christian Giammichele and Patrick Levesque

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Nature of the Genetic Difficulty

Generalized hypertrichosis terminalis is believed to be caused by genetic mutations on chromosome 17, in which the addition and removal of many nucleotides is the result. In addition, the MAP2K6 gene is possibly a factor that contributes to the disease. The change in the chromosomes affecting the transcription of genes is due to this same disease.

Basis Facts of Disease

Hypertrichosis, also known as Ambras Syndrome or more commonly known as "Wolf Man Syndrome" is a mutation of the body that results in abnormal hair growth. Hypertrichosis is either generalized or spread over the entire body, or localized, and located in one certain area. Generalized hypertrichosis terminalis is the most common trype of hypertrichosis, although there are many other forms, either congenital or acquired. The difference between these two are that congenital appears at birth and acquired will show up over a span of time after birth.

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Congenital types include:
- Hypertrichosis lanuginosa
- Generalized hypertrichosis
- Terminal hypertrichosis
- Circumscribed hypertrichosis
- Localized hypertrichosis
- Nevoid hypertrichosis

Acquired types include:
- Hypertrichosis lanuginosa
- Generalized hypertrichosis
- Patterned hypertrichosis
- Localized hypertrichosis


There is no cure for the disease of hypertrichosis, however there are some alternatives of handling the abnormal hair growth. These are mainly cosmetic and include laser hair removal and continual shaving, waxing, chemical work on the skin, or electrology. Each procedure has its possible side effects, however, the mutation of hypertrichosis cannot be treated or removed from the body.

Sources Cited